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Hantavirus comes home: what American employers need to know

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The risk to the broader public, health authorities are emphatic, is low. “We do know that you can get small clusters of disease, but in 30 years we’ve never seen any large outbreaks,” Khan told NPR. “This is unlikely to become a pandemic.”

For American employers and HR professionals, however, the situation asks a specific and practical question: when a deadly, slow-incubating infectious disease starts dispersing into the American workforce — across multiple states, with no symptoms and no test that can confirm exposure before illness — what exactly is your organization supposed to do?

What the Andes strain is, and why it is unusual

Hantavirus is not unfamiliar on American soil. From 1993 through 2023, the CDC recorded 890 laboratory-confirmed cases in the United States, caused mainly by the Sin Nombre virus, which spreads through contact with infected deer mice and is concentrated in the rural Southwest and Great Plains. It does not pass between people.


World’s deadliest pandemics & outbreaks

Estimated death tolls — log scale. All figures are historical estimates and carry significant uncertainty.

Bacterial Viral Parasitic

Smallpox 300M, Black Death 75M, HIV/AIDS 40M, Spanish Flu 50M, Plague of Justinian 25M, COVID-19 7M confirmed, Antonine Plague 5M, WWI-era Typhus 3M, Third Cholera Pandemic 1M, Malaria 0.6M annual.

* Log scale: each gridline represents a 10× increase in deaths. Used because the range spans from ~600K to ~300M.

* Black Death: scholarly estimates range from 75M to 200M. 75M used as conservative consensus figure.

* Spanish Flu (1918–19): estimates range from 20M to 50M. 50M used as upper scholarly estimate.

* HIV/AIDS: ~40M cumulative deaths since 1981; still ongoing (~600K deaths/year).

* Plague of Justinian: highly contested — estimates range 15M to 100M. 25M used as traditional conservative figure; recent scholarship (Mordechai & Eisenberg, 2019) argues the toll may be significantly lower.

* COVID-19: ~7M confirmed deaths (WHO); excess mortality estimates range 15M–27M.

* Smallpox: 300M figure covers the 20th century only (pre-eradication 1977). Total historical deaths estimated 300–500M+.

* Malaria: shown as a modern annual death toll (~620K/year per WHO 2022), not a single-outbreak cumulative figure. Historical total may exceed 50–60M.

Sources: WHO, CDC, Our World in Data, Britannica, PNAS (Mordechai & Eisenberg 2019), MPH Online, Live Science, History Hit.

The Andes virus is different in one critical respect: it is the only hantavirus documented to transmit between humans. That transmission remains rare and demands prolonged, close physical contact with a symptomatic person — sharing a bed, intimate contact, or sustained proximity in caregiving. It is emphatically not airborne in the way influenza or Covid-19 are.

“This is a very different virus,” Maria Van Kerkhove, WHO director for epidemic and pandemic preparedness and prevention, told a news briefing last week. The disease cannot spread through a shared elevator or an open-plan office.

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